Perspectives

Clinical Thinking,
Shared Openly

How we evaluate evidence, make decisions, and navigate the boundary between what medicine knows and what it doesn't — yet.

Evidence Review Kendrick Lopez, MD April 6, 2026

What Changed in March and Why It Matters for Your Arteries

The 2026 ACC/AHA lipid guidelines rewrote the rules on cholesterol management. LDL targets are back. ApoB and Lp(a) are no longer optional. And imaging has a clearer role than ever.

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Essay Kendrick Lopez, MD April 13, 2026

The Label Problem

Functional, integrative, precision, longevity. There are too many names for this kind of medicine, and most of them don't help patients nearly as much as they think they do.

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Evidence Review Kendrick Lopez, MD March 30, 2026

The Number Your Doctor Has Never Measured

VO₂ max is the single strongest predictor of longevity in the medical literature. Stronger than smoking, hypertension, and coronary artery disease. Almost no one measures it.

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Evidence Review Kendrick Lopez, MD February 26, 2026

What Your Annual Physical Actually Misses

A Cochrane review of 250,000 participants found annual physicals don't reduce mortality. Here's what the standard visit misses, what the evidence says you should be measuring instead, and why the format is the problem.

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Evidence Review Kendrick Lopez, MD February 25, 2026

Let's Start with Peptides...

A member texted at 9pm: "What about peptides?" Here's what we told her — and what the evidence actually says about BPC-157, GHK-Cu, and the difference between promising and proven.

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